Endocrine Abstracts

Immune-checkpoint inhibitors have become important elements of oncology therapy in recent years. These monoclonal antibodies block immune-checkpoints, unleashing T cells to fight cancer. However, immune-checkpoints also play an important role in the prevention of autoimmune processes and immune-checkpoint inhibitor therapy can also trigger autoimmune adverse effects, termed immune-related adverse events. Endocrinopathies are among the most common immune-related side effects.</...

Introduction: Acromegaly is usually caused by pituitary macroadenoma producing excess growth hormone. Treatment options include surgery to remove the tumor, medications, and radiation therapy.Case report: A 39-year-old woman has been referred to the endocrine clinic with suspected acromegaly in December 2019. Surgery for benign ovarian cyst, endometriosis, amenorrhoea, unsuccessful in vitro fertilisations were present in her medical history. She complain...

Long-term follow-up of differentiated thyroid cancer (DTC) patients requires yearly measurements of serum thyroglobulin (Tg) levels is endogenous (4 weeks off-thyroxin) or exogenous (human recombinant TSH injection) high TSH state. Subclinical hyperthyroidism is maintained in the patients throughout the rest of the year. We examined the endothelial function, hemostasis factors and metabolic parameters in short-term iatrogenic hypothyroidism (HO) and in subclinical hyperthyroid...

Drinking water is the major natural source of iodine in many European countries. In the present study, we examined possible sites of iodine loss during the usual water purification process. Water samples from 6 sites during the technological process were taken and analyzed for iodine content. Under laboratory circumstances, prepared iodine in water solution has been used as a model to test the effect of the presence of chlorine. Samples from the purification sites revealed tha...

Objectives: Glucocorticoids (GCs) are the first line therapy in moderate to severe, active thyroid eye disease (TED). While their beneficial immunosuppressive effects are well known, direct connective tissue effects are less characterized. The accumulation of extracellular matrix component hyaluronan (HA) and increased proliferation rate of fibroblasts are hallmarks connective tissue changes in TED. We examined the effect of methylprednisolone (MP), prednisolone (P), hydrocort...

Graves’ orbitopathy (GO) is a common complication of Graves’ disease (GD) which is often responding poorly to therapy. GO may develop before or together with, or during the course of GD. In an individual patient, the development of GO cannot be predicted. We assumed that orbital autoimmune activity is predictable using orbital 99mTc-labelled diethylenetriamine pentaacetic acid (99mTc-DTPA) SPECT. We aimed to determine whether any orbital autoimmune activity can be id...

Objective: Multiple endocrine neoplasia type 1 (MEN1) is a rare heritable tumor syndrome caused by germline mutations of MEN1 gene affecting mainly the parathyroid, pituitary and pancreas. Phenotype varies widely, even in first-degree relatives. Recently it has been shown that functionally active gastroenteropancreatic neuroendocrine tumors (GEP-NETs), initially frequently diagnosed as sporadic cases, lead to MEN1 diagnosis. Non-functioning tumors are increasingly rec...